Your care team will continuously support you throughout treatment

It’s important to tell your care team about side effects right away, if you:

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    First experience of

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    Feel that the side effects are affecting daily activities

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    Have been treating side effects according to your doctor’s instructions but they do not improve

Your experience may vary. If you experience any of the following symptoms of side effects, tell your doctor right away.

Use a treatment journal to document how you're feeling throughout treatment. You can download the journal here.

Possible serious side effects of RYBREVANT® + LAZCLUZE™ include:

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Infusion-related reactions

-related reactions are common but can be severe or serious and can include life-threatening (anaphylaxis) allergic reaction. Most occur during the first infusion.

Tell your doctor right away if you experience:

  • Shortness of breath, difficulty breathing, or wheezing
  • Flushing
  • Chest discomfort
  • Skin rash, hives, or itching
  • Swelling of your eyes, lips, or tongue
  • Nausea or vomiting
  • Fever
  • Stomach cramps
  • Chills
  • Lightheadedness, dizziness, or fainting
  • Numbness of the tongue, lips, cheeks, or gums
  • Headache
  • Flushing
  • Skin rash, hives, or itching
  • Nausea or vomiting
  • Stomach cramps
  • Lightheadedness, dizziness, or fainting
  • Headache

If you experience an infusion-related reaction: Your treatment team may adjust or pause your infusion dosing and timing to help manage the reaction.

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Lung problems

RYBREVANT® may cause lung problems that may lead to death. Symptoms of lung problems may be similar to those from your lung cancer.

Tell your doctor right away if you experience any new or worsening lung symptoms, including:

  • Shortness of breath
  • Cough
  • Fever
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Blood clots

When RYBREVANT® is given in combination with LAZCLUZE™, blood clots are a serious but common side effect. This can occur in the veins of your legs or lungs.

Tell your doctor right away if you experience:

  • Swelling
  • Pain or tenderness in the leg
  • Sudden unexplained chest pain
  • Shortness of breath

To help prevent blood clots: Your doctor will start you on a medicine for the first 4 months of treatment.

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Skin problems

You may experience severe rash.

Tell your doctor right away if you experience:

  • Blisters
  • Peeling
  • Skin pain and sores
  • Redness
  • Raised, acne-like bumps
  • Itching
  • Dry skin

If you experience skin problems: Your doctor may treat you with a medicine(s) or send you to see a skin specialist (dermatologist).

What you can do: Taking certain steps can help lower your risk of skin-related side effects. Learn more here. Or, click here for a downloadable guide of tips and reminders to help throughout treatment.

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Eye problems

You may experience eye problems.

Tell your doctor right away if you experience:

  • Eye pain
  • Inflammation of eye lids
  • Dry eyes
  • Eye redness
  • Sensitivity to light
  • Blurred vision
  • Changes in vision
  • Itchy eyes
  • Excessive tearing
  • Changes in vision
  • Itchy eyes
  • Excessive tearing
  • Sensitivity to light

If you experience eye problems: Your doctor may send you to see an eye specialist (ophthalmologist).

What you can do: You should not use contact lenses until your eye symptoms are checked by a doctor.

Harm to your unborn baby

RYBREVANT® + LAZCLUZE™ can harm your unborn baby. 

Tell your doctor right away if you become pregnant or think you might be pregnant.

What you can do: If you are able to become pregnant, you should use effective birth control during treatment and for 3 months after your final
dose of RYBREVANT®, and during treatment and for 3 weeks after your last dose of LAZCLUZE™.

Most common side effects of RYBREVANT® + LAZCLUZE™

  • Rash
  • Infected skin around the nail
  • Muscle and joint pain
  • Sores in the mouth
  • Swelling of hands, ankles, feet, face, or all of your body
  • Unusual feeling in the skin (such as tingling or crawling feeling)
  • Feeling very tired
  • Diarrhea
  • Constipation
  • COVID-19
  • Dry skin
  • Bleeding
  • Decreased appetite
  • Itchy skin
  • Nausea
  • Changes in certain blood tests

Your care team can help prevent or manage side effects to help you stay on treatment.

*Mutations include exon 19 deletion or exon 21 L858R substitution mutations.

EGFR+ = mutated epidermal growth factor receptor; NSCLC = non–small cell lung cancer

Always tell your care team if you experience side effects, so you can help manage them together.

Treatment Brochure

A general guide to help manage your treatment experience.

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1st treatment of NSCLC with common EGFR mutations with RYBREVANT® + LAZCLUZE™ brochure thumbnail1st treatment of NSCLC with common EGFR mutations with RYBREVANT® + LAZCLUZE™ brochure thumbnail

Savings & support

Once prescribed a RYBREVANT®-based treatment, connect with a Care Navigator for your support needs.

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The support and resources provided by RYBREVANT withMe are not intended to provide medical advice, replace a treatment plan you receive from your doctor or nurse, or serve as a reason for you to start or stay on treatment.